Heron Therapeutics to Present at the Leerink Partners 2015 Global Healthcare Conference
A live webcast of this presentation will be available on the Company’s website at www.herontx.com in the Investors section. A replay of the presentation will be archived on the site for 90 days.
Heron's lead investigational product candidate, SUSTOL® (granisetron injection, extended release), is being developed for the prevention of both acute- and delayed-onset chemotherapy induced nausea and vomiting (CINV). One of the most debilitating side effects of cancer chemotherapy, CINV is a leading cause of premature discontinuation of treatment. There is only one injectable 5-HT3 receptor antagonist approved for the prevention of delayed-onset CINV in patients receiving moderately emetogenic chemotherapy (MEC); none are approved for delayed-onset CINV in patients receiving highly emetogenic chemotherapy (HEC). SUSTOL contains the 5-HT3 receptor antagonist granisetron formulated in the Company's proprietary Biochronomer® polymer-based drug delivery platform, which has been shown in clinical studies to maintain therapeutic drug levels of SUSTOL for up to five days with a single subcutaneous injection. Currently available intravenous and oral formulations of granisetron are approved only for the prevention of acute-onset CINV. Granisetron was selected for SUSTOL because it is widely prescribed by physicians based on a well-established record of safety and efficacy.
About HTX-019 for Chemotherapy Induced Nausea and Vomiting
HTX-019 is a proprietary intravenous formulation of aprepitant, an NK1 receptor antagonist. HTX-019 does not contain polysorbate 80, which may cause hypersensitivity reactions in some patients. At present, there is only one intravenous NK1 receptor antagonist approved in the U.S. for the prevention of CINV. NK1 receptor antagonists are used in combination with a 5-HT3 receptor antagonist for the prevention of CINV.
About HTX-011 for Post-Operative Pain
HTX-011 is a combination of local anesthetic bupivacaine and the anti-inflammatory meloxicam in a novel formulation utilizing Heron’s proprietary Biochronomer polymer-based drug delivery platform. In an animal model of post-surgical pain, HTX-011 significantly reduced pain through 72 hours.
About HTX-003 for Chronic Pain and Addiction
HTX-003 is a long-acting formulation of buprenorphine for the management of chronic pain and opioid addiction. Utilizing Heron’s proprietary Biochronomer polymer-based drug delivery platform, HTX-003 is designed to maintain therapeutic drug levels of buprenorphine for 30 days following a single subcutaneous injection, with low potential for patient abuse.
Forward Looking Statements
This news release contains "forward-looking statements" as defined by
the Private Securities Litigation Reform Act of 1995. Heron cautions
readers that forward-looking statements are subject to certain risks and
uncertainties that could cause actual results to differ materially.
These risks and uncertainties include those associated with the timing
of completion of the HEC study, and the results thereof, and the NDA
resubmission for SUSTOL, potential regulatory approval of SUSTOL and the
timing for such approval, if approved at all; risks relating to progress
in research and development of HTX-019, HTX-011, HTX-003 and our other
product candidate programs, including the timing of planned toxicology
and clinical studies; the risk that safety and efficacy data from our
clinical studies may not warrant further development of our product
candidates, risks related to the launch and acceptance of new products
generally; risks related to our financial position and our ability to
raise additional capital to fund operations if necessary or to pursue
additional business opportunities; risks related to strategic business
alliances we may pursue or the potential acquisition of other products
or technologies and other risks and uncertainties identified in the
Company's filings with the
Heron Therapeutics, Inc.
Investor Relations Contact:
Jennifer Capuzelo, 858-703-6063
Sr. Manager, Investor Relations
Barry D. Quart, 650-366-2626
Pharm D., Chief Executive Officer