As filed with the Securities and Exchange Commission on May 25, 2004
                                       Registration No. 333-115163

                   SECURITIES AND EXCHANGE COMMISSION
                         WASHINGTON, D.C. 20549

                             AMENDMENT NO.1
                                   TO
                                FORM S-3
                        REGISTRATION STATEMENT
                  UNDER THE SECURITIES ACT OF 1933

                           A.P. Pharma, Inc.
                     ------------------------------
        (Exact name of registrant as specified in its charter)

Delaware                                              94-2875566
- -------------------------------              -------------------
(State or other jurisdiction of              (I.R.S. employer
 incorporation or organization)              identification no.)

123 Saginaw Drive, Redwood City, California 94063 (650) 366-2626
- ----------------------------------------------------------------
(Address, including zip code, and telephone number, including
    area code, of registrant's principal executive offices)


                         Michael P.J. O'Connell
                President and Chief Executive Officer
                          A.P. Pharma, Inc.
                          123 Saginaw Drive
                  Redwood City, California  94063
                         (650) 366-2626
              ---------------------------------------
              (Name, address, including zip code, and
               telephone number, including area code,
                      of agent for service)

                            Copies to:
                      Richard A. Peers, Esq.
                 Heller Ehrman White & McAuliffe LLP
                        2775 Sand Hill Road
                  Menlo Park, California  94025
                      (650) 324-7000 (phone)
                       (650) 324-0638 (fax)

Approximate date of commencement of proposed sale to the public:
From time to time or at one time after the effective date of the Registration
Statement as the Registrant shall determine.

If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the
following box.[ ]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or
interest reinvestment plans, check the following box.[X]

If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act of 1933, please check the
following box and list the Securities Act registration statement number of the
earlier effective registration statement for the same offering.[ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act of 1933, check the following box and list the Securities
Act registration statement number of the earlier effective registration
statement for the same offering.[ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.[ ]



                                   Part II

Item 16.  Exhibits.

The following documents are filed herewith (unless otherwise indicated) and
made a part of this registration statement.

      Exhibit                       Description
       Number                        of Exhibit
      -------                       -----------

	1.1(1)        Form of Underwriting Agreement
	5.1           Opinion of Heller Ehrman White & McAuliffe LLP
	23.1           Consent of Heller Ehrman White & McAuliffe LLP (filed as
                      part of Exhibit 5.1)
	23.2*          Consent of Ernst & Young LLP, Independent Auditors
	24.1*          Power of Attorney

- ------------
* Previously filed as an exhibit to this registration statement.

(1)  To be filed by amendment or as an exhibit to a current report on Form 8-K
and incorporated herein by reference.


SIGNATURES Pursuant to the requirements of the Securities Act of 1933, Registrant ccertifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Amendment No. 1 to Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in Redwood City, State of California, on May 25, 2004. A.P. PHARMA, INC. By: /S/ Michael P.J. O'Connell --------------------------- Michael P.J. O'Connell President and Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 1 to Registration Statement on Form S-3 has been signed by the following persons on behalf of the Registrant and in the capacities and on the dates indicated. SIGNATURE TITLE DATE - ----------------------------------------------------------------- /S/ Michael O'Connell President and Chief May 25, 2004 - ---------------------- Executive Officer ------------ Michael P.J. O'Connell (Principal Executive Officer) /S/ Gordon Sangster Chief Financial Officer May 25, 2004 - ---------------------- (Principal Accounting ------------ Gordon Sangster Officer) /S/ Paul Goddard* Chairman of the Board May 25, 2004 - ---------------------- of Directors ------------ Paul Goddard /S/ Stephen Drury* Director May 25, 2004 - ---------------------- ------------ Stephen Drury /S/ Peter Riepenhausen* Director May 25, 2004 - ---------------------- ------------ Peter Riepenhausen /S/ Toby Rosenblatt* Director May 25, 2004 - ---------------------- ------------ Toby Rosenblatt /S/ Gregory H. Turnbull* Director May 25, 2004 - ---------------------- ------------ Gregory H. Turnbull /S/ Dennis Winger* Director May 25, 2004 - ---------------------- ------------ Dennis Winger /S/ Robert Zerbe* Director May 25, 2004 - ---------------------- ------------ Robert Zerbe /S/ Michael P.J. O'Connell - -------------------------- Michael P.J. O'Connell *(Attorney-in-fact) EXHIBIT INDEX ------------- Exhibit Description Number of Exhibit - ------- ----------- 1.1(1) Form of Underwriting Agreement 5.1 Opinion of Heller, Ehrman, White & McAuliffe LLP 23.1 Consent of Heller, Ehrman, White & McAuliffe (filed as part of Exhibit 5.1) 23.2* Consent of Ernst & Young LLP, Independent Auditors 24.1* Power of Attorney * Previously filed as an exhibit to this registration statement. (1) To be filed by amendment or as an exhibit to a current report on Form 8-K and incorporated herein by reference. (Footnote continued)

                                                                  Exhibit 5.1

[Letterhead of Heller Ehrman White & McAuliffe LLP]

May 25, 2004

                                                           Main (650) 324-7000
                                                            Fax (650) 324-0638

                                                                    10008-0006
A.P. Pharma, Inc.
123 Saginaw Drive
Redwood City, California  94063

                      Registration Statement on Form S-3
                      ----------------------------------

Ladies and Gentlemen:

We have acted as counsel to A.P. Pharma, Inc., a Delaware corporation (the
"Company"), in connection with the Amendment No. 1 to the Registration
Statement on Form S-3 (the "Registration Statement") which the Company
proposes to file with the Securities and Exchange Commission on or about May
25, 2004 for the purpose of registering under the Securities Act of 1933, as
amended, shares of its Common Stock, par value $.01, (the "Shares"), with an
aggregate offering price of up to $15,000,000.  The Shares are to be sold from
time to time as set forth in the Registration Statement, the prospectus
contained therein (the "Prospectus") and the supplements to the Prospectus
(the "Prospectus Supplements").  The Shares may be sold pursuant to a
definitive underwriting, purchase or similar agreement (the "Underwriting
Agreement") to be filed under a Current Report on Form 8-K or an amendment to
the Registration Statement.

We have assumed the authenticity of all records, documents and instruments
submitted to us as originals, the genuineness of all signatures, the legal
capacity of natural persons and the conformity to the originals of all
records, documents and instruments submitted to us as copies.

In rendering our opinion, we have examined the following records, documents
and instruments:

(a)	The Certificate of Incorporation of the Company, certified by the
Delaware Secretary of State as of April 30, 2004, and certified to us by an
officer of the Company as being complete and in full force as of the date of
this opinion;

(b)	The Bylaws of the Company certified to us by an officer of the Company
as being complete and in full force and effect as of the date of this opinion;

(c)	A Certificate of an officer of the Company (i) attaching records
certified to us as constituting all records of proceedings and actions of the
Board of Directors, including any committee thereof, and stockholders of the
Company relating to the Shares, and the Registration Statement, and (ii)
certifying as to certain factual matters;

(d)	The Registration Statement;

(e)	A Certificate of Status - Foreign Corporation relating to the Company
issued by the Secretary of State of the State of California dated April 30,
2004;

(f)	A letter from the Franchise Tax Board of the State of California dated
April 30, 2004 stating that the Company is in good standing with that agency;

(g)	A Certificate of Good Standing relating to the Company issues by the
Secretary of State of the State of Delaware, dated April 30, 2004; and

(h)	A letter from the Company's transfer agent, dated May 25, 2004, as to
the number of shares of the Company's Common Stock that were outstanding on
May 25, 2004.

This opinion is limited to the federal law of the United States of America and
the General Corporation Law of the State of Delaware, and we disclaim any
opinion as to the laws of any other jurisdiction.  We further disclaim any
opinion as to any other statute, rule, regulation, ordinance, order or other
promulgation of any other jurisdiction or any regional or local governmental
body or as to any related judicial or administrative opinion.

Based upon the foregoing and our examination of such questions of law as we
have deemed necessary or appropriate for the purpose of this opinion, and
assuming that (i) the Registration Statement, as finally amended (including
all post-effective amendments), has become effective and remains effective
during the period when the Shares are offered and sold; (ii) an appropriate
Prospectus Supplement with respect to the Shares has been prepared, filed and
delivered in compliance with the Securities Act and the applicable rules and
regulations thereunder; (iii) if the Shares are to be sold pursuant to an
Underwriting Agreement, such Underwriting Agreement with respect to the Shares
has been duly authorized, executed and delivered by the Company and the other
parties thereto; (iv) the Board, including any appropriate committee appointed
thereby, and appropriate officers of the Company have taken all necessary
corporate action to approve the issuance of the Shares and all matters related
thereto; (v) the Shares have been offered, issued and sold in accordance with
the terms of the Registration Statement, or any post-effective amendment
thereto, and any Prospectus and Prospectus Supplement relating thereto; (vi)
there are a sufficient number of authorized but unissued shares of Common
Stock reserved for issuance when the Shares are offered and sold; (vii)
appropriate certificates evidencing the Shares have been executed and
delivered by the Company; (viii) the full consideration stated in the
Underwriting Agreement, or as otherwise contemplated by the Registration
Statement, or any post-effective amendment thereto, and any Prospectus and
Prospectus Supplement relating thereto, has been paid for the Shares; and (ix)
all applicable securities laws have been complied with, it is our opinion
that, when issued and sold by the Company, the Shares will be validly issued,
fully paid and nonassessable.

This opinion is rendered to you in connection with the Registration Statement
and is solely for your benefit.  This opinion may not be relied upon by you
for any other purpose, or relied upon by any other person, firm, corporation
or other entity for any purpose, without our prior written consent.  We
disclaim any obligation to advise you of any change of law that occurs, or any
facts of which we may become aware, after the date of this opinion.
We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement and to the reference to this firm under the caption
"Legal Matters" in the Registration Statement, the Prospectus, any Prospectus
Supplement, and in any amendment or supplement thereto.

                                       Very truly yours,

                                       /s/ Heller Ehrman White & McAuliffe LLP
                                       ---------------------------------------
                                       Heller Ehrman White & McAuliffe LLP