UNITED STATES
             SECURITIES AND EXCHANGE COMMISSION
                  Washington, D.C.  20549




                           FORM 8-K

                        CURRENT REPORT
               Pursuant to Section 13 or 15(d) of
               the Securities Exchange Act of 1934

Date of Report (Date of Earliest Event Reported):
                                                November 11, 2005
                                                -----------------

                       A.P. PHARMA, INC.
    ------------------------------------------------------
    (Exact name of Registrant as specified in its charter)


          DELAWARE                 1-16109          94-2875566
- ----------------------------    ----------    -----------------
(State or other jurisdiction    (Commission       (IRS Employer
      of incorporation)         File Number)  Identification No.)


       123 SAGINAW DRIVE, REDWOOD CITY, CALIFORNIA  94063
     --------------------------------------------------------
     (Address of principal executive offices)       (Zip code)

      Registrant's telephone number, including area code:
                       (650) 366-2626
                       --------------

                             N/A
    -------------------------------------------------------------
    (Former Name or Former Address, if Changed Since Last Report)




               INFORMATION TO BE INCLUDED IN THE REPORT

ITEM 3.01 Notice of Delisting or Failure to Satisfy a Continued
Listing Rule or Standard; Transfer of Listing

REDWOOD CITY, Calif. (November 16, 2005) - A.P. Pharma, Inc.
(NASDAQ NM: APPA), a specialty pharmaceutical company, today
reported that on November 11, 2005, the Company was advised by
the NASDAQ Listing Qualifications Department that NASDAQ is
reviewing the Company's eligibility for continued listing on the
NASDAQ National Market as the Company does not comply with the
NASDAQ's minimum $10 million stockholders' equity requirement set
forth in Marketplace Rule 4450(a)(3).  To facilitate the review,
the Company has been asked to provide on or before November 28,
2005 a specific plan and timeframe to achieve and sustain
compliance with all NASDAQ National Market listing requirements.

The Company is currently evaluating a variety of financing
alternatives, some of which could resolve the listing deficiency,
and is planning to prepare the plan requested by NASDAQ.  If the
plan is not accepted by the NASDAQ or if the financing
alternative selected by the Company does not resolve the listing
deficiency, the Company is in compliance with the current listing
standards of the NASDAQ Capital Market.



                         SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of
1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned hereunto duly authorized.

                                  A.P. PHARMA, INC.


Date: November 16, 2005              By: /S/ Michael O'Connell
     ------------------                 ----------------------
                                        Michael P. J. O'Connell,
                                        President and Chief
                                        Executive Officer



                        EXHIBIT INDEX

99.1   Press release dated November 16, 2005.

(continued from previous page)


Exhibit 99.1

A.P. Pharma Logo

News Release

       A.P. PHARMA REPORTS RECEIPT OF NOTICE FROM NASDAQ

REDWOOD CITY, Calif. (November 16, 2005) - A.P. Pharma, Inc.
(NASDAQ NM: APPA), a specialty pharmaceutical company, today
reported that on November 11, 2005, the Company was advised
by the NASDAQ Listing Qualifications Department that NASDAQ
is reviewing the Company's eligibility for continued listing
on the NASDAQ National Market as the Company does not comply
with the NASDAQ's minimum $10 million stockholders' equity
requirement set forth in Marketplace Rule 4450(a)(3).  To
facilitate the review, the Company has been asked to provide
on or before November 28, 2005 a specific plan and timeframe
to achieve and sustain compliance with all NASDAQ National
Market listing requirements.

The Company is currently evaluating a variety of financing
alternatives, some of which could resolve the listing
deficiency, and is planning to prepare the plan requested by
NASDAQ.  If the plan is not accepted by the NASDAQ or if the
financing alternative selected by the Company does not
resolve the listing deficiency, the Company is in compliance
with the current listing standards of the NASDAQ Capital
Market.

About A.P. Pharma
- -----------------

A.P. Pharma is a specialty pharmaceutical company focused on
the development of ethical (prescription) pharmaceuticals
utilizing its proprietary polymer-based drug delivery
systems.  The Company's primary focus is the development and
commercialization of its bioerodible injectable and
implantable systems under the trade name Biochronomer.
Initial target areas of application for the Company's drug
delivery technology include anti-nausea, pain management,
inflammation and ophthalmic applications.  The Company's
product development programs are funded by the sale of
common stock in June 2004, royalties from topical products
currently marketed by pharmaceutical partners, proceeds from
the divestitures of its cosmeceutical and analytical
standards product lines and by fees it receives from
collaborative partners.  For further information visit the
Company's web site at www.appharma.com.

Forward-looking Statements
- --------------------------

Except for historical information, this news release
contains certain forward-looking statements that involve
risks and uncertainties including, among others, uncertainty
associated with the Company's ability to satisfy Nasdaq
listing requirements, timely development, approval, launch
and acceptance of new products, establishment of new
corporate alliances and progress in research and development
programs.  Other risks and uncertainties associated with the
Company's business and prospects are identified in the
Company's filings with the Securities and Exchange
Commission.  The Company does not undertake to revise these
forward-looking statements to reflect events or
circumstances occurring in the future.

Investor Relations Contacts:                Company Contact:
Lippert/Heilshorn & Associates	               Gordon Sangster
Zachary Bryant (zbryant@lhai.com)    Chief Financial Officer
Jody Cain (jcain@lhai.com)                    (650) 366-2626
Bruce Voss (bvoss@lhai.com)
(310) 691-7100