UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                A.P. Pharma, Inc.
                                (Name of Issuer)

                Shares of Common Stock, par value $0.01 per share
                         (Title of Class of Securities)

                                    00202J203
                                 (CUSIP Number)

                                  June 14, 2007
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





- ----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).










                               Page 1 of 10 Pages





CUSIP No. 00202J203                     13G                  Page 2 of 10 Pages


- -----------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Highbridge International LLC
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            Cayman Islands, British West Indies
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         --------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,412,121 shares of Common Stock
OWNED BY       --------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      --------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
             1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                    [ ]
- -----------------------------------------------------------------------
     (11)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (9)
             5.12%
- -----------------------------------------------------------------------
     (12)    TYPE OF REPORTING PERSON **
             OO
- -----------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00202J203                     13G                  Page 3 of 10 Pages


- -----------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Highbridge Capital Management, LLC
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            State of Delaware
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         --------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,412,121 shares of Common Stock
OWNED BY       --------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      --------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
             1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                    [ ]
- -----------------------------------------------------------------------
     (11)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (9)
             5.12%
- -----------------------------------------------------------------------
     (12)    TYPE OF REPORTING PERSON **
             OO
- -----------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 00202J203                     13G                  Page 4 of 10 Pages


- -----------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Glenn Dubin
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         --------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,412,121 shares of Common Stock
OWNED BY       --------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      --------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
             1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                    [ ]
- -----------------------------------------------------------------------
     (11)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (9)
             5.12%
- -----------------------------------------------------------------------
     (12)    TYPE OF REPORTING PERSON **
             IN
- -----------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00202J203                     13G                  Page 5 of 10 Pages


- -----------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Henry Swieca
- -----------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
- -----------------------------------------------------------------------
     (3)    SEC USE ONLY
- -----------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- -----------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         --------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,412,121 shares of Common Stock
OWNED BY       --------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      --------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
             1,412,121 shares of Common Stock
- -----------------------------------------------------------------------
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                    [ ]
- -----------------------------------------------------------------------
     (11)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (9)
             5.12%
- -----------------------------------------------------------------------
     (12)    TYPE OF REPORTING PERSON **
             IN
- -----------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00202J203                     13G                  Page 6 of 10 Pages


Item 1.

(a)  Name of Issuer

        A.P. Pharma, Inc. (the "Company").

(b)  Address of Issuer's Principal Executive Offices

        123 Saginaw Drive
        Redwood City, CA 94063

Item 2(a).  Name of Person Filing
Item 2(b).  Address of Principal Business Office
Item 2(c).  Citizenship


        HIGHBRIDGE INTERNATIONAL LLC
        c/o Harmonic Fund Services
        The Cayman Corporate Centre, 4th Floor
        27 Hospital Road
        Grand Cayman, Cayman Islands, British West Indies
        Citizenship:  Cayman Islands, British West Indies

        HIGHBRIDGE CAPITAL MANAGEMENT, LLC   IRS #: 20-1901985
        9 West 57th Street, 27th Floor
        New York, New York  10019
        Citizenship:  State of Delaware

        GLENN DUBIN
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:  United States

        HENRY SWIECA
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:  United States


Item 2(d)   Title of Class of Securities

            Common Stock, $0.01 par value ("Common Stock")

Item 2(e)   CUSIP Number

            00202J203

Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b)
  or (c), check whether the person filing is a:

(a) [ ] Broker or dealer registered under Section 15 of the Act (15 U.S.C.
        78o).

(b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ] Insurance company as defined in Section 3(a)(19) of the Act





CUSIP No. 00202J203                     13G                  Page 7 of 10 Pages


        (15 U.S.C. 78c).

(d) [ ] Investment company registered under Section 8 of the Investment
        Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

(f) [ ] An employee benefit plan or endowment fund in accordance with Rule
        13d-1(b)(1)(ii)(F);

(g) [ ] A parent holding company or control person in accordance with Rule
        13d-1(b)(1)(ii)(G);

(h) [ ] A savings association as defined in Section 3(b) of the Federal
        Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ] A church plan that is excluded from the definition of an investment
        company under Section 3(c)(14) of the Investment Company Act of 1940
        (15 U.S.C. 80a-3);

(j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. [X]

Item 4. Ownership

        Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

        (a) Amount beneficially owned:

            As of the date of this filing, (i) Highbridge International LLC is
the beneficial owner of 1,412,121 shares of Common Stock and (ii) each of
Highbridge Capital Management, LLC, Glenn Dubin and Henry Swieca may be deemed
the beneficial owner of the 1,412,121 shares of Common Stock beneficially owned
by Highbridge International LLC.

            Highbridge Capital Management, LLC is the trading manager of
Highbridge International LLC. Glenn Dubin is a Co-Chief Executive Officer of
Highbridge Capital Management, LLC. Henry Swieca is a Co-Chief Executive Officer
of Highbridge Capital Management, LLC. The foregoing should not be construed in
and of itself as an admission by any Reporting Person as to beneficial ownership
of the shares of Common Stock owned by another Reporting Person. In addition,
each of Highbridge Capital Management, LLC, Glenn Dubin and Henry Swieca
disclaims beneficial ownership of the shares of Common Stock owned by Highbridge
International LLC.


        (b) Percent of class:

            The Company's Prospectus filed pursuant to Rule 424(b)(4) on June
14, 2007, indicates that the total number of outstanding shares of Common Stock
upon completion of the offering made pursuant to such Prospectus is 27,571,787.
Therefore, based on the Company's outstanding shares of Common Stock, each of
Highbridge International LLC, Highbridge Capital Management, LLC, Glenn Dubin
and Henry Swieca may be deemed to beneficially own 5.12% of the outstanding
Common Shares of the Company. The foregoing should not be construed in and of
itself as an admission by any Reporting Person as to beneficial ownership of
shares of Common Shares owned by another Reporting Person.





CUSIP No. 00202J203                     13G                  Page 8 of 10 Pages




        (c) Number of shares as to which such person has:

            (i)   Sole power to vote or to direct the vote

                  0

            (ii)  Shared power to vote or to direct the vote

                  See Item 4(a)

            (iii) Sole power to dispose or to direct the disposition of

                  0

            (iv)  Shared power to dispose or to direct the disposition of

                  See Item 4(a)

Item 5. Ownership of Five Percent or Less of a Class

        Not applicable.

Item 6. Ownership of More than Five Percent on Behalf of Another Person

        Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired
        the Security Being Reported on by the Parent Holding Company or
        Control Person

        Not applicable.

Item 8. Identification and Classification of Members of the Group

        See Exhibit I.

Item 9. Notice of Dissolution of Group

        Not applicable.

Item 10. Certification

         By signing below each of the undersigned certifies that, to the best
of its knowledge and belief, the securities referred to above were not acquired
and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.

Exhibits:

Exhibit I: Joint Filing Agreement, dated as of June 22, 2007, by and among
Highbridge International LLC, Highbridge Capital Management, LLC, Glenn Dubin
and Henry Swieca.






CUSIP No. 00202J203                     13G                 Page 9 of 10 Pages


SIGNATURES

        After reasonable inquiry and to the best of its knowledge and belief,
each of the undersigned certifies that the information with respect to it set
forth in this statement is true, complete, and correct.

Dated: June 22, 2007


HIGHBRIDGE INTERNATIONAL LLC                  HIGHBRIDGE CAPITAL MANAGEMENT, LLC

By: Highbridge Capital Management, LLC
    its Trading Manager

                                              By: /s/ Carolyn Rubin
By: /s/ Carolyn Rubin                             -------------------------
    -------------------------                     Name: Carolyn Rubin
Name: Carolyn Rubin                               Title: Managing Director
Title: Managing Director




/s/ Glenn Dubin                               /s/ Henry Swieca
- ----------------------------                  -----------------------------
GLENN DUBIN                                   HENRY SWIECA






CUSIP No. 00202J203                     13G                 Page 10 of 10 Pages


                                    EXHIBIT I

                             JOINT FILING AGREEMENT

This will confirm the agreement by and among the undersigned that the Schedule
13G filed with the Securities and Exchange Commission on or about the date
hereof with respect to the beneficial ownership by the undersigned of the Common
Shares, $0.01 par value, of A.P. Pharma, Inc., is being filed, and all
amendments thereto will be filed, on behalf of each of the persons and entities
named below in accordance with Rule 13d-1(k) under the Securities Exchange Act
of 1934, as amended. This Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

Dated as of June 22, 2007



HIGHBRIDGE INTERNATIONAL LLC                  HIGHBRIDGE CAPITAL MANAGEMENT, LLC

By: Highbridge Capital Management, LLC
    its Trading Manager

                                              By: /s/ Carolyn Rubin
By: /s/ Carolyn Rubin                             -------------------------
    -------------------------                     Name: Carolyn Rubin
Name: Carolyn Rubin                               Title: Managing Director
Title: Managing Director




/s/ Glenn Dubin                               /s/ Henry Swieca
- ----------------------------                  -----------------------------
GLENN DUBIN                                   HENRY SWIECA